3FNU

Crystal structure of KNI-10006 bound histo-aspartic protease (HAP) from Plasmodium falciparum

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	HAP protein	polymer	332	37435.3	4	UniProt (Q8IM15) Pfam (PF00026)	Plasmodium falciparum
2	E, F, G, H (A, B, C, D)	(4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide	non-polymer		631.8	4	BIRD (PRD_000575) Chemie (006)
3	I, J, K, L (A, B, C, D)	water	water		18.0	95	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149741.0
Non-Polymers*	Number of molecules	4
	Total formula weight	2527.1
All*	Total formula weight	152268.1

*Water molecules are not included.