3F78

Crystal structure of wild type LFA1 I domain complexed with isoflurane

Summary for 3F78

• Entry DOI: 10.2210/pdb3f78/pdb
• Related: 3F74
• Descriptor: Integrin alpha-L, 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER, GLYCEROL, ... (5 entities in total)
• Functional Keywords: integrin, lfa1, i domain, inactive conformation, wild type, volatile anesthetic, isoflurane, inhibitor of integrin, cell adhesion, glycoprotein, magnesium, membrane, receptor, transmembrane
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P20701
• Total number of polymer chains: 3
• Total formula weight: 62980.96

Authors

Zhang, H.,Wang, J.-H. (deposition date: 2008-11-07, release date: 2009-06-23, Last modification date: 2023-09-06)

• Primary citation: Zhang, H.,Astrof, N.S.,Liu, J.H.,Wang, J.H.,Shimaoka, M.; Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.; Faseb J., 23:2735-2740, 2009; PubMed: 19332643; DOI: 10.1096/fj.09-129908

Experimental method

X-RAY DIFFRACTION (1.6 Å)