3EWJ
Crystal structure of catalytic domain of TACE with carboxylate inhibitor
Summary for 3EWJ
Entry DOI | 10.2210/pdb3ewj/pdb |
Related | 1bkc 2fv9 3e8r |
Related PRD ID | PRD_000919 |
Descriptor | ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (5 entities in total) |
Functional Keywords | tace, adam17, hydrolase, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 62347.39 |
Authors | Orth, P. (deposition date: 2008-10-15, release date: 2008-11-18, Last modification date: 2023-09-06) |
Primary citation | Guo, Z.,Orth, P.,Wong, S.C.,Lavey, B.J.,Shih, N.Y.,Niu, X.,Lundell, D.J.,Madison, V.,Kozlowski, J.A. Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors. Bioorg.Med.Chem.Lett., 19:54-57, 2009 Cited by PubMed: 19054672DOI: 10.1016/j.bmcl.2008.11.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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