2FV9
Crystal structure of TACE in complex with JMV 390-1
Summary for 2FV9
Entry DOI | 10.2210/pdb2fv9/pdb |
Related | 1bkc 2ddf 2fv5 |
Related PRD ID | PRD_000919 |
Descriptor | ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (5 entities in total) |
Functional Keywords | tace adam33 zn-endopeptidase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 59243.07 |
Authors | Orth, P. (deposition date: 2006-01-30, release date: 2006-03-14, Last modification date: 2023-08-30) |
Primary citation | Ingram, R.N.,Orth, P.,Strickland, C.L.,Le, H.V.,Madison, V.,Beyer, B.M. Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies. Protein Eng.Des.Sel., 19:155-161, 2006 Cited by PubMed: 16459338DOI: 10.1093/protein/gzj014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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