2FV9
Crystal structure of TACE in complex with JMV 390-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | ADAM 17 | polymer | 258 | 29123.6 | 2 | UniProt (P78536) Pfam (PF13688) In PDB | Homo sapiens (human) | A disintegrin and metalloproteinase domain 17, TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, CD156b antigen |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A | N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide | non-polymer | 415.5 | 1 | BIRD (PRD_000919) Chemie (INN) | |||
| 4 | B | N-[(2R)-2-BENZYL-4-(HYDROXYAMINO)-4-OXOBUTANOYL]-L-ISOLEUCYL-L-LEUCINE | non-polymer | 449.5 | 1 | Chemie (002) | |||
| 5 | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A, B: 218 - 475 (UniProt: P78536)
| PDB | External Database | Details |
|---|---|---|
| Ala 266 | Ser 266 | engineered mutation |
| Gly 353 | Val 353 | engineered mutation |
| Gln 452 | Asn 452 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58247.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 995.9 | |
| All* | Total formula weight | 59243.1 |
