3EQS

Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor

Summary for 3EQS

Entry DOI	10.2210/pdb3eqs/pdb
Related	1RV1 1T4E 1T4F 1YCR
Descriptor	E3 ubiquitin-protein ligase Mdm2, 12-mer peptide inhibitor, GUANIDINE, ... (4 entities in total)
Functional Keywords	mdm2, mdm2-peptide inhibitor complex, oncoprotein, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	2
Total formula weight	11531.52
Authors	Pazgier, M.,Lu, W. (deposition date: 2008-10-01, release date: 2009-03-17, Last modification date: 2023-09-06)
Primary citation	Pazgier, M.,Liu, M.,Zou, G.,Yuan, W.,Li, C.,Li, C.,Li, J.,Monbo, J.,Zella, D.,Tarasov, S.G.,Lu, W. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc.Natl.Acad.Sci.USA, 106:4665-4670, 2009 Cited by PubMed: 19255450 DOI: 10.1073/pnas.0900947106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation