3EID

CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor

Summary for 3EID

Entry DOI	10.2210/pdb3eid/pdb
Descriptor	Cell division protein kinase 2, Cyclin-A2, (2S)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol, ... (4 entities in total)
Functional Keywords	cdk2, cyclin, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	128178.56
Authors	Steven, K.,Reno, M.,Alberti, J.,Price, D.,Kane-Carson, L.,Knick, V.,Shewchuk, L.,Hassell, A.,Veal, J.,Peel, M. (deposition date: 2008-09-15, release date: 2008-10-21, Last modification date: 2023-08-30)
Primary citation	Stevens, K.L.,Reno, M.J.,Alberti, J.B.,Price, D.J.,Kane-Carson, L.S.,Knick, V.B.,Shewchuk, L.M.,Hassell, A.M.,Veal, J.M.,Davis, S.T.,Griffin, R.J.,Peel, M.R. Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18:5758-5762, 2008 Cited by PubMed: 18835709 DOI: 10.1016/j.bmcl.2008.09.069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation