3EB1
Crystal structure PTP1B complex with small molecule inhibitor LZP-25
Summary for 3EB1
Entry DOI | 10.2210/pdb3eb1/pdb |
Related | 3EAX |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase, ptp1b, inhibitor, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37753.07 |
Authors | Liu, S.,Zheng, L.-F.,Wu, L.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.-Q.,Zhang, Z.-Y. (deposition date: 2008-08-26, release date: 2009-07-07, Last modification date: 2024-02-21) |
Primary citation | Liu, S.,Zeng, L.F.,Wu, L.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.Q.,Zhang, Z.Y. Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. J.Am.Chem.Soc., 130:17075-17084, 2008 Cited by PubMed: 19012396DOI: 10.1021/ja8068177 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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