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3EB1

Crystal structure PTP1B complex with small molecule inhibitor LZP-25

Summary for 3EB1
Entry DOI10.2210/pdb3eb1/pdb
Related3EAX
DescriptorTyrosine-protein phosphatase non-receptor type 1, 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid (3 entities in total)
Functional Keywordsprotein tyrosine phosphatase, ptp1b, inhibitor, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
Biological sourceHomo sapiens (Human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight37753.07
Authors
Liu, S.,Zheng, L.-F.,Wu, L.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.-Q.,Zhang, Z.-Y. (deposition date: 2008-08-26, release date: 2009-07-07, Last modification date: 2024-02-21)
Primary citationLiu, S.,Zeng, L.F.,Wu, L.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.Q.,Zhang, Z.Y.
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J.Am.Chem.Soc., 130:17075-17084, 2008
Cited by
PubMed: 19012396
DOI: 10.1021/ja8068177
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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