3EAX

Crystal structure PTP1B complex with small molecule compound LZP-6

Summary for 3EAX

Entry DOI	10.2210/pdb3eax/pdb
Related	3EB1
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, 4,4'-piperazine-1,4-diylbis{1-[3-(benzyloxy)phenyl]-4-oxobutane-1,3-dione} (3 entities in total)
Functional Keywords	protein tyrosine phosphatase, ptp1b, inhibitor, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	38012.32
Authors	Zhang, Z.-Y.,Liu, S.,Zhang, L.-F.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.-Q. (deposition date: 2008-08-26, release date: 2009-07-07, Last modification date: 2024-02-21)
Primary citation	Liu, S.,Zeng, L.F.,Wu, L.,Yu, X.,Xue, T.,Gunawan, A.M.,Long, Y.Q.,Zhang, Z.Y. Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. J.Am.Chem.Soc., 130:17075-17084, 2008 Cited by PubMed: 19012396 DOI: 10.1021/ja8068177 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation