3DOK

Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248.

Summary for 3DOK

Entry DOI	10.2210/pdb3dok/pdb
Related	3DLE 3DLG 3DM2 3DMJ 3DOL
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	hiv-1 reverse transcriptase, aids, nnrti, gw678248, drug resistance, hydrolase, transferase
Biological source	Human immunodeficiency virus type 1 (HIV-1) More
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains	2
Total formula weight	116577.18
Authors	Chamberlain, P.P.,Ren, J.,Stammers, D.K. (deposition date: 2008-07-04, release date: 2008-08-12, Last modification date: 2023-08-30)
Primary citation	Ren, J.,Chamberlain, P.P.,Stamp, A.,Short, S.A.,Weaver, K.L.,Romines, K.R.,Hazen, R.,Freeman, A.,Ferris, R.G.,Andrews, C.W.,Boone, L.,Chan, J.H.,Stammers, D.K. Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51:5000-5008, 2008 Cited by PubMed: 18665583 DOI: 10.1021/jm8004493 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation