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3DJK

Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0255A

Summary for 3DJK
Entry DOI10.2210/pdb3djk/pdb
Related2HB3 2IEN 2Z4O 3DK1
DescriptorProtease, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordshiv-1, wild type protease, protease inhibitor, hydrolase, aids, aspartyl protease, capsid maturation, capsid protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, lipoprotein, magnesium, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, ribosomal frameshifting, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
Cellular locationGag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains2
Total formula weight22184.36
Authors
Wang, Y.F.,Weber, I.T. (deposition date: 2008-06-23, release date: 2008-09-30, Last modification date: 2023-11-01)
Primary citationGhosh, A.K.,Gemma, S.,Baldridge, A.,Wang, Y.F.,Kovalevsky, A.Y.,Koh, Y.,Weber, I.T.,Mitsuya, H.
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies
J.Med.Chem., 51:6021-6033, 2008
Cited by
PubMed: 18783203
DOI: 10.1021/jm8004543
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1 Å)
Structure validation

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