3CU0
human beta 1,3-glucuronyltransferase I (GlcAT-I) in complex with UDP and GAL-GAL(6-SO4)-XYL(2-PO4)-O-SER
Summary for 3CU0
Entry DOI | 10.2210/pdb3cu0/pdb |
Related | 1FGG 1KWS |
Descriptor | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, beta-D-galactopyranose-(1-3)-beta-D-galactopyranose, MANGANESE (II) ION, ... (6 entities in total) |
Functional Keywords | glcat-i, glycosyltransferase, heparan sulfate biosynthesis, glycoprotein, golgi apparatus, manganese, membrane, metal-binding, signal-anchor, transmembrane, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus membrane; Single-pass type II membrane protein: O94766 |
Total number of polymer chains | 2 |
Total formula weight | 64121.78 |
Authors | Tone, Y.,Pedersen, L.C.,Yamamoto, T.,Kitagawa, H.,Nishihara-Shimizu, J.,Tamura, J.,Negishi, M.,Sugahara, K. (deposition date: 2008-04-15, release date: 2008-05-06, Last modification date: 2023-08-30) |
Primary citation | Tone, Y.,Pedersen, L.C.,Yamamoto, T.,Izumikawa, T.,Kitagawa, H.,Nishihara, J.,Tamura, J.,Negishi, M.,Sugahara, K. 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. J.Biol.Chem., 283:16801-16807, 2008 Cited by PubMed: 18400750DOI: 10.1074/jbc.M709556200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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