3COJ

Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1

Summary for 3COJ

• Entry DOI: 10.2210/pdb3coj/pdb
• Related: 1T15 1T29 1T2V 1Y98 2AZM
• Descriptor: Breast cancer type 1 susceptibility protein, Acetyl-CoA carboxylase 1 (2 entities in total)
• Functional Keywords: breast cancer, ovarian cancer, fatty acid biosynthesis, lipid synthesis, obesity, protein-peptide complex, protein protein interaction, anti-oncogene, cell cycle, disease mutation, dna damage, dna repair, dna-binding, metal-binding, nucleus, phosphoprotein, zinc-finger, alternative promoter usage, atp-binding, biotin, ligase, manganese, multifunctional enzyme, nucleotide-binding, antitumor protein-ligase complex, antitumor protein/ligase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398; Cytoplasm: Q13085
• Total number of polymer chains: 16
• Total formula weight: 225945.22

Authors

Shen, Y.,Tong, L. (deposition date: 2008-03-28, release date: 2008-05-27, Last modification date: 2023-08-30)

• Primary citation: Shen, Y.,Tong, L.; Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1; Biochemistry, 47:5767-5773, 2008; PubMed: 18452305; DOI: 10.1021/bi800314m

Experimental method

X-RAY DIFFRACTION (3.21 Å)