3CLD
Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate
Summary for 3CLD
Entry DOI | 10.2210/pdb3cld/pdb |
Related | 1m2z |
Descriptor | Glucocorticoid receptor, Tif2 coactivator motif, (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate, ... (4 entities in total) |
Functional Keywords | glucocorticoid receptor, gr, nuclear receptor, alternative initiation, chromatin regulator, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, pseudohermaphroditism, steroid-binding, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform Beta: Nucleus: P04150 |
Total number of polymer chains | 4 |
Total formula weight | 64006.35 |
Authors | Shewchuk, L.M.,McLay, I.,Stewart, E.,Biggadike, K.B.,Hassell, A.M.,Bledsoe, R.K. (deposition date: 2008-03-18, release date: 2008-06-24, Last modification date: 2023-08-30) |
Primary citation | Biggadike, K.,Bledsoe, R.K.,Hassell, A.M.,Kirk, B.E.,McLay, I.M.,Shewchuk, L.M.,Stewart, E.L. X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain. J.Med.Chem., 51:3349-3352, 2008 Cited by PubMed: 18522385DOI: 10.1021/jm800279t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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