3CLD
Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Glucocorticoid receptor | polymer | 259 | 29985.8 | 2 | UniProt (P04150) Pfam (PF00104) In PDB | Homo sapiens (Human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | H, C | Tif2 coactivator motif | polymer | 12 | 1478.8 | 2 | UniProt (by SIFTS) (Q15596) In PDB | ||
| 3 | A, B | (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate | non-polymer | 538.6 | 2 | Chemie (GW6) | |||
| 4 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B: 521 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Tyr 602 | Phe 602 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62929.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1077.2 | |
| All* | Total formula weight | 64006.4 |
