3CLD
Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Glucocorticoid receptor | polymer | 259 | 29985.8 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B, D (H, C) | Tif2 coactivator motif | polymer | 12 | 1478.8 | 2 | UniProt (by SIFTS) (Q15596) | ||
| 3 | E, F (A, B) | (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate | non-polymer | 538.6 | 2 | Chemie (GW6) PubChem (20734893) PubChem (24775951) PubChem (24847878) PubChem (23658408) PubChem (57688088) PubChem (87073368) PubChem (87100177) PubChem (87237605) PubChem (87306813) PubChem (87354324) PubChem (87660673) PubChem (87872484) PubChem (87910174) PubChem (177323721) PubChem (89855669) PubChem (90788774) PubChem (87290238) PubChem (87629110) PubChem (89332779) PubChem (91885052) PubChem (117951645) PubChem (129460976) PubChem (9854489) PubChem (122667793) PubChem (138655017) PubChem (11432650) PubChem (142271975) PubChem (159932720) PubChem (129373344) PubChem (129460975) PubChem (135324388) PubChem (142271972) PubChem (142853504) PubChem (142853508) PubChem (143546011) PubChem (146158826) PubChem (168312334) PubChem (169445785) PubChem (172012977) PubChem (172873948) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B: 521 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Tyr 602 | Phe 602 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62929.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1077.2 | |
| All* | Total formula weight | 64006.4 |
