3C5D

Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to lividomycin

Summary for 3C5D

Entry DOI	10.2210/pdb3c5d/pdb
Related	2QEK 3C3Z 3C44
Descriptor	'HIV-1 subtype F genomic RNA, POTASSIUM ION, (2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R ,5S,6R)-3-AMINO-5-HYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-4-HYDROXY-2-(HYDROXYMET HYL)-TETRAHYDROFURAN-3-YLOXY)-4-HYDROXY-TETRAHYDRO-2H-PYRAN-3-YLOXY)-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL, ... (4 entities in total)
Functional Keywords	hiv-1, rna, aminoglycoside, lividomycin, extended duplex
Total number of polymer chains	2
Total formula weight	16528.65
Authors	Freisz, S.,Lang, K.,Micura, R.,Dumas, P.,Ennifar, E. (deposition date: 2008-01-31, release date: 2008-05-06, Last modification date: 2023-11-01)
Primary citation	Freisz, S.,Lang, K.,Micura, R.,Dumas, P.,Ennifar, E. Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site. Angew.Chem.Int.Ed.Engl., 47:4110-4113, 2008 Cited by PubMed: 18435520 DOI: 10.1002/anie.200800726 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation