3C4F
FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole
Summary for 3C4F
Entry DOI | 10.2210/pdb3c4f/pdb |
Related | 3C4C 3C4D 3C4E |
Descriptor | Basic fibroblast growth factor receptor 1, 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (3 entities in total) |
Functional Keywords | fibroblast growth factor receptor, tyrosine kinase domain, receptor tyrosine kinase, fgfr1, fgfr, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, dwarfism, glycoprotein, heparin-binding, immunoglobulin domain, kallmann syndrome, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 69452.03 |
Authors | Zhang, K.Y.J.,Wang, W. (deposition date: 2008-01-29, release date: 2008-02-26, Last modification date: 2024-02-21) |
Primary citation | Tsai, J.,Lee, J.T.,Wang, W.,Zhang, J.,Cho, H.,Mamo, S.,Bremer, R.,Gillette, S.,Kong, J.,Haass, N.K.,Sproesser, K.,Li, L.,Smalley, K.S.,Fong, D.,Zhu, Y.L.,Marimuthu, A.,Nguyen, H.,Lam, B.,Liu, J.,Cheung, I.,Rice, J.,Suzuki, Y.,Luu, C.,Settachatgul, C.,Shellooe, R.,Cantwell, J.,Kim, S.H.,Schlessinger, J.,Zhang, K.Y.,West, B.L.,Powell, B.,Habets, G.,Zhang, C.,Ibrahim, P.N.,Hirth, P.,Artis, D.R.,Herlyn, M.,Bollag, G. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proc.Natl.Acad.Sci.Usa, 105:3041-3046, 2008 Cited by PubMed: 18287029DOI: 10.1073/pnas.0711741105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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