3C27
Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors
Summary for 3C27
Entry DOI | 10.2210/pdb3c27/pdb |
Related | 2R2M |
Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin-3A, ... (5 entities in total) |
Functional Keywords | thrombin, serine protease, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28507 |
Total number of polymer chains | 3 |
Total formula weight | 34702.56 |
Authors | Spurlino, J.C.,McMillan, M.,Lewandowski, F.,Milligan, C. (deposition date: 2008-01-24, release date: 2009-02-17, Last modification date: 2011-07-13) |
Primary citation | Kreuter, K.D.,Lee, L.,Lu, T.,Giardino, E.C.,Patel, S.,Haung, H.,Xu, G.,Fitzgerald, M.,Mohan, M.,Crysler, C.,Eisennagel, S.,Dasgupta, M.,McMillan, M.,Spurlino, J.C.,Heubert, N.,Maryanoff, B.E.,Tomczuk, B.E.,Damiano, B.P.,Player, M.R. Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (2.182 Å) |
Structure validation
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