3BKI

Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms

Summary for 3BKI

• Entry DOI: 10.2210/pdb3bki/pdb
• Related: 3BKG
• Descriptor: Glutamate receptor 2, [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide (3 entities in total)
• Functional Keywords: ampa receptor, anqx, quinoxaline-2, 3-diones, alternative splicing, cell junction, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphoprotein, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, transport protein
• Biological source: Rattus norvegicus (rat); More
• Total number of polymer chains: 4
• Total formula weight: 117767.30

Authors

Cruz, L.,Estebanez-Perpina, E.,Pfaff, S.,Borngraeber, S.,Bao, N.,Fletterick, R.,England, P. (deposition date: 2007-12-06, release date: 2008-09-16, Last modification date: 2019-09-04)

• Primary citation: Cruz, L.A.,Estebanez-Perpina, E.,Pfaff, S.,Borngraeber, S.,Bao, N.,Blethrow, J.,Fletterick, R.J.,England, P.M.; 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor.; J.Med.Chem., 51:5856-5860, 2008; PubMed: 18754610; DOI: 10.1021/jm701517b

Experimental method

X-RAY DIFFRACTION (1.87 Å)