3BKI

Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
P	0015276	molecular_function	ligand-gated monoatomic ion channel activity
P	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FQX P 264

Chain	Residue
P	TYR16
P	HOH476
P	TYR61
P	PRO89
P	LEU90
P	THR91
P	ARG96
P	MET196
P	TYR220
P	HOH420

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE FQX B 264

Chain	Residue
B	TYR16
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLU193
B	MET196
B	TYR220
B	HOH341
B	HOH361
B	HOH362
B	HOH381

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FQX C 264

Chain	Residue
C	TYR16
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLU193
C	MET196
C	TYR220
C	HOH292
C	HOH309
C	HOH438

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FQX D 264

Chain	Residue
D	TYR16
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	GLU193
D	MET196
D	TYR220
D	HOH359
D	HOH378
D	HOH480

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
P	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
D	PRO89
P	THR91
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
P	ARG96
P	SER142
P	THR143
P	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
P	ARG64
D	ARG64
D	ARG148
D	LYS240
P	ARG148
P	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
P	ILE121
B	ILE121
C	ILE121
D	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
P	SER150
B	SER150
C	SER150
D	SER150

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
P	SER184
B	SER184
C	SER184
D	SER184

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
P	ASN3
B	ASN3
C	ASN3
D	ASN3

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