3BEG

Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2

Summary for 3BEG

Entry DOI	10.2210/pdb3beg/pdb
Descriptor	Serine/threonine-protein kinase SRPK1, Splicing factor, arginine/serine-rich 1, PHOSPHOSERINE, ... (5 entities in total)
Functional Keywords	kinase, sr protein kinase, sr protein, pre-mrna splicing, atp-binding, chromosome partition, differentiation, mrna processing, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, methylation, rna-binding, spliceosome, transferase-splicing complex, transferase/splicing
Biological source	Homo sapiens (human) More
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cytoplasm: Q96SB4 Cytoplasm : Q07955
Total number of polymer chains	2
Total formula weight	57183.68
Authors	Ngo, J.C.,Giang, K.,Chakrabarti, S.,Ma, C.-T.,Huynh, N.,Hagopian, J.,Dorrestein, P.C.,Fu, X.-D.,Adams, J.A.,Ghosh, G. (deposition date: 2007-11-18, release date: 2008-04-01, Last modification date: 2024-02-21)
Primary citation	Ngo, J.C.,Giang, K.,Chakrabarti, S.,Ma, C.-T.,Huynh, N.,Hagopian, J.,Dorrestein, P.C.,Fu, X.-D.,Adams, J.A.,Ghosh, G. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1 Mol.Cell, 29:563-576, 2008 Cited by PubMed: 18342604 DOI: 10.1016/j.molcel.2007.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation