3B7R

Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040

Summary for 3B7R

Entry DOI	10.2210/pdb3b7r/pdb
Related	2R59 3B7S 3B7T 3B7U
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total)
Functional Keywords	transition state, analogue peptide, hydrolysis, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, zinc
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	70787.60
Authors	Tholander, F.,Haeggstrom, J.,Thunnissen, M.,Muroya, A.,Roques, B.-P.,Fournie-Zaluski, M.-C. (deposition date: 2007-10-31, release date: 2008-09-16, Last modification date: 2023-08-30)
Primary citation	Tholander, F.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C.,Thunnissen, M.M.,Haeggstrom, J.Z. Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15:920-929, 2008 Cited by PubMed: 18804029 DOI: 10.1016/j.chembiol.2008.07.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.811 Å)

Structure validation