2R59

Leukotriene A4 hydrolase complexed with inhibitor RB3041

Summary for 2R59

Entry DOI	10.2210/pdb2r59/pdb
Related	1GW6 1H19 1HS6 1SQM
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total)
Functional Keywords	transition state, analogue peptide, hydrolysis, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, zinc
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	70854.67
Authors	Tholander, F.,Haeggstrom, J.Z.,Thunnissen, M.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C. (deposition date: 2007-09-03, release date: 2008-08-12, Last modification date: 2024-04-03)
Primary citation	Tholander, F.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C.,Thunnissen, M.M.,Haeggstrom, J.Z. Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15:920-929, 2008 Cited by PubMed: 18804029 DOI: 10.1016/j.chembiol.2008.07.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation