Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B7R

Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0003723	molecular_function	RNA binding
L	0004177	molecular_function	aminopeptidase activity
L	0004301	molecular_function	epoxide hydrolase activity
L	0004463	molecular_function	leukotriene-A4 hydrolase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006508	biological_process	proteolysis
L	0006629	biological_process	lipid metabolic process
L	0006691	biological_process	leukotriene metabolic process
L	0008233	molecular_function	peptidase activity
L	0008237	molecular_function	metallopeptidase activity
L	0008270	molecular_function	zinc ion binding
L	0010043	biological_process	response to zinc ion
L	0016787	molecular_function	hydrolase activity
L	0019370	biological_process	leukotriene biosynthetic process
L	0043171	biological_process	peptide catabolic process
L	0043434	biological_process	response to peptide hormone
L	0045148	molecular_function	tripeptide aminopeptidase activity
L	0046872	molecular_function	metal ion binding
L	0060509	biological_process	type I pneumocyte differentiation
L	0070006	molecular_function	metalloaminopeptidase activity
L	0070062	cellular_component	extracellular exosome
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN L 701

Chain	Residue
L	HIS295
L	HIS299
L	GLU318

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE YB L 801

Chain	Residue
L	HOH1657
L	ASP47
L	ASP481
L	HOH1444
L	HOH1447
L	HOH1543
L	HOH1609

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD L 802

Chain	Residue
L	GLY344
L	GLY347
L	GLU348
L	ASN351
L	GLU501
L	ALA504
L	GLN508

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE BIR L 1001

Chain	Residue
L	GLN136
L	TYR267
L	GLY268
L	GLY269
L	GLU271
L	ASN291
L	HIS295
L	GLU296
L	HIS299
L	GLU318
L	TYR378
L	TYR383
L	ARG563
L	LYS565
L	HOH1005
L	HOH1064
L	HOH1391

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHEISHSW

Chain	Residue	Details
L	VAL292-TRP301

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18804029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11917124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15078870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18804029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19618939","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3U9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DPR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3U9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DPR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Pro-Gly-Pro binding","evidences":[{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Essential for epoxide hydrolase activity, but not for aminopeptidase activity","evidences":[{"source":"PubMed","id":"11917124","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Covalently modified during suicide inhibition by leukotrienes","evidences":[{"source":"PubMed","id":"7667299","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9395533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1h19

Chain	Residue	Details
L	TYR383
L	GLU296
L	GLU271

site_id	MCSA1
Number of Residues	7
Details	M-CSA 166

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)