38LQ

Structure of Staphylococcus aureus Y131F DNA gyrase GK-del fusion construct in complex with 20 bp DNA and OSU-276

This is a non-PDB format compatible entry.

Summary for 38LQ

• Entry DOI: 10.2210/pdb38lq/pdb
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit A, DNA (5'-D(P*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: topoisomerase, nbti, dna gyrase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 4
• Total formula weight: 169793.80

Authors

Tomaszewski, A.J.,Bell, C.E. (deposition date: 2026-09-02, release date: 2026-10-21)

• Primary citation: Cassel, S.R.,Powell, J.P.,Wheat, C.T.,Tomaszewski, A.J.,Dellos-Nolan, S.,Landgraf, A.D.,Sham, M.P.,Chen, A.,Bell, C.E.,Wozniak, D.J.,Yalowich, J.C.,Mitton-Fry, M.J.; OSUAB-0276, a Novel Bacterial Topoisomerase Inhibitor (NBTI) with Dual Activity Against Bacterial and Human Type II Topoisomerases; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.836 Å)