37DK

Discovery of CNS Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers

This is a non-PDB format compatible entry.

Summary for 37DK

• Entry DOI: 10.2210/pdb37dk/pdb
• Descriptor: Transthyretin, 1-(3,5-dimethyl-1H-pyrazol-4-yl)-4-phenylpiperidine (3 entities in total)
• Functional Keywords: transthyretin, stabilizer, heterocyclic, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 28065.44

Authors

Liu, S.,Wu, X.,Liu, S.,Wu, H. (deposition date: 2026-07-15, release date: 2026-10-07)

• Primary citation: Wang, T.,Thuma, B.A.,Wisniewska, H.M.,Lee Johnson, Z.,Tu, M.,Byrnes, L.J.,Cabral, S.,Canterbury, D.P.,Clemens, J.,Coffey, S.B.,Dow, R.,Dowling, M.S.,Fensome, A.,Fleming, J.,Futatsugi, K.,Kalgutkar, A.S.,Korczynska, M.,Kung, D.W.,Lapham, K.,Lavergne, S.Y.,Limberakis, C.,Liu, S.,Londregan, A.T.,Loria, P.M.,Mascitti, V.,Moody, A.T.,Novak, J.J.,Piotrowski, D.W.,Sharma, R.,Shavnya, A.,Stock, I.A.,Tess, D.A.,Tsai, A.S.,Wei, L.,Wenzel, Z.,Wu, H.; Discovery of Neutral and Cerebrospinal Fluid Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c02318

Experimental method

X-RAY DIFFRACTION (1.163 Å)