37DK

Discovery of CNS Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transthyretin	polymer	127	13777.4	2	UniProt (P02766) Pfam (PF00576)	Homo sapiens (human)	ATTR,Prealbumin,TBPA
2	C, D (A, B)	1-(3,5-dimethyl-1H-pyrazol-4-yl)-4-phenylpiperidine	non-polymer		255.4	2	Chemie (A1DMZ)
3	E, F (A, B)	water	water		18.0	285	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27554.7
Non-Polymers*	Number of molecules	2
	Total formula weight	510.7
All*	Total formula weight	28065.4

*Water molecules are not included.