36CA

Dehydrogenase AprD5 complexed with NAD and UDP-beta-D-Glucose

This is a non-PDB format compatible entry.

Summary for 36CA

• Entry DOI: 10.2210/pdb36ca/pdb
• Descriptor: Nucleoside-diphosphate-sugar epimerase, [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl dihydrogen diphosphate, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: aminosugar biosynthesis; nad-dependent oxidoreductase; short-chain dehydrogenase/reductase (sdr); 4-dehydrogenation, oxidoreductase
• Biological source: Streptoalloteichus tenebrarius
• Total number of polymer chains: 2
• Total formula weight: 79468.16

Authors

Kim, W.,Zhang, Y.J. (deposition date: 2026-05-29, release date: 2026-10-07)

• Primary citation: Kim, W.,Hong, Y.,Sato, S.,Liu, H.W.,Zhang, Y.J.; Structural and Mechanistic Insights into 4'-Dehydrogenation Catalyzed by AprD5 in Apramycin Biosynthesis; Biochemistry, 2026; DOI: 10.1021/acs.biochem.6c00553

Experimental method

X-RAY DIFFRACTION (1.87 Å)