35VB

Crystal structure of KRAS G13C (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of BRAF

Summary for 35VB

• Entry DOI: 10.2210/pdb35vb/pdb
• Descriptor: Isoform 2B of GTPase KRas, Serine/threonine-protein kinase B-raf, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (8 entities in total)
• Functional Keywords: kras, ras, k-ras, kras4b, braf, rbd, crd, ras-binding domain, cysteine-rich domain, rbd-crd, rbdcrd. brs, bsr, oncoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 35764.05

Authors

Tran, T.H.,Bonsor, D.A.,Simanshu, D.K. (deposition date: 2026-05-19, release date: 2026-09-23)

• Primary citation: Bonsor, D.A.,Sandin Lawrence, S.I.,Tran, T.H.,Swain, M.,Dharmaiah, S.,Mehalko, J.,Messing, S.A.,Nissley, D.V.,McCormick, F.,Stephen, A.G.,Simanshu, D.K.; Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific region; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.85 Å)