35UH

Crystal structure of TFPI K2 domain in complex with TFPI-23 Fab fragment

Summary for 35UH

• Entry DOI: 10.2210/pdb35uh/pdb
• Descriptor: TFPI-23-Fab Heavy chain, TFPI-23-Fab Light chain, Tissue factor pathway inhibitor (3 entities in total)
• Functional Keywords: tissue factor pathway inhibitor, antibody, fab fragment, tfpi, kunitz domain, factor xa, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 18
• Total formula weight: 323837.41

Authors

Juo, Z.S.,Bard, J.,Mosyak, L. (deposition date: 2026-05-18, release date: 2026-05-27)

• Primary citation: Jin, M.,Hett, S.,Jasuja, R.,Rakhe, S.,Narula, J.,Tam, A.,Apgar, J.R.,Juo, Z.S.,Mosyak, L.,Holsti, M.,Joyce, A.,Hurst, S.,Webster, R.,Lin, L.,Stahl, M.,Pittman, D.D.,Bloom, L.; Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.11 Å)