35UC

Crystal structure of 2-amino-[1,2,4]triazolo[1,5-a]pyridine derivative bound to KIT

This is a non-PDB format compatible entry.

Summary for 35UC

• Entry DOI: 10.2210/pdb35uc/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, 2-[4-(2-azanyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazol-1-yl]-~{N}-(2-fluoranyl-4-methyl-phenyl)ethanamide (3 entities in total)
• Functional Keywords: kit inhibitor, tyrosine kinase inhibitor, gatekeeper, juxtamembrane, inflammation, allergy, chronic urticaria, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 38925.95

Authors

Walker, N.P.,Jeffrey, J.L.,Blaesse, M. (deposition date: 2026-05-18, release date: 2026-09-16)

• Primary citation: Moon, H.,Yan, X.,Zhu, J.,Mata, G.,Wang, Z.,Haelsig, K.T.,Schweickert, P.G.,Sivick, K.E.,Huang, H.T.,Van Abbema, A.M.,Chen, S.,Zhao, X.,Green, D.W.,Jin, L.,Young, S.W.,Walters, M.J.,Walker, N.P.,Leleti, M.R.,Powers, J.P.,Jeffrey, J.L.; Leveraging Structure-Based Design to Overcome Class III RTK Off-Target Activity in the Development of Selective Wild-Type KIT Inhibitors; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c01334

Experimental method

X-RAY DIFFRACTION (2.328 Å)