35UC
Crystal structure of 2-amino-[1,2,4]triazolo[1,5-a]pyridine derivative bound to KIT
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | Mast/stem cell growth factor receptor Kit | polymer | 339 | 38560.6 | 1 | UniProt (P10721) Pfam (PF07714) | Homo sapiens (human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | B (AAA) | 2-[4-(2-azanyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazol-1-yl]-~{N}-(2-fluoranyl-4-methyl-phenyl)ethanamide | non-polymer | 365.4 | 1 | Chemie (A1DMF) | |||
| 3 | C (AAA) | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
AAA: 544 - 751 (UniProt: P10721)
AAA: 752 - 935 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Gly 539 | - | expression tag |
| Pro 540 | - | expression tag |
| Met 541 | - | expression tag |
| Asp 542 | - | expression tag |
| Pro 543 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 753 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38560.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 365.4 | |
| All* | Total formula weight | 38925.9 |
