33CH

Cryo-EM structure of MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-4

Summary for 33CH

• Entry DOI: 10.2210/pdb33ch/pdb
• Related: 33CG
• EMDB information: 59343
• Descriptor: MHC class I antigen, Beta-2-microglobulin, Melanoma-associated antigen 4, ... (8 entities in total)
• Functional Keywords: hla, mhc, antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 147474.94

Authors

Schuster, S.,Weng, T.-H.,Reinhart, C.,Michel, H.,Birkenfeld, J. (deposition date: 2026-08-09, release date: 2026-08-26)

• Primary citation: Schuster, S.,Hartl, F.A.,Stehle, J.,Beier, F.,Al-Hasani, H.,Reinhart, C.,Weng, T.-H.,Kraemer, S.,Hamde, P.,Herz, T.,Oesterlin, S.,Schmidt, M.,Gross, T.,Stehl, L.,Kilb, N.,Juenemann, G.,Heiss, K.,Sinclair, A.,Schoettgen, J.,Meyer, P.,Atay, B.,Zaghla, B.K.Q.,Link, S.,Goll, J.,Leoni, B.,Steinmann, B.,Selinger, O.,Welsch, S.,Roth, G.,Michel, H.,Klatt, M.,Birkenfeld, J.; Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.4 Å)