32JY

Structure of the pathogenic variant G423S of Human SHMT2

Summary for 32JY

Entry DOI	10.2210/pdb32jy/pdb
Related	32JA 32JC 32JD 32JN
Descriptor	Serine hydroxymethyltransferase, mitochondrial, 1,4-BUTANEDIOL, 1,3-PROPANDIOL, ... (6 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	216571.37
Authors	Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S. (deposition date: 2026-07-13, release date: 2026-09-02)
Primary citation	Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S. Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome To Be Published,
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation