32JY
Structure of the pathogenic variant G423S of Human SHMT2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine hydroxymethyltransferase, mitochondrial | polymer | 486 | 54067.2 | 4 | UniProt (P34897) | Homo sapiens (human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 2 | E (A) | 1,4-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU1) PubChem (8064) | |||
| 3 | F (A) | 1,3-PROPANDIOL | non-polymer | 76.1 | 1 | Chemie (PDO) PubChem (10442) | |||
| 4 | G (A) | 1-BUTANOL | non-polymer | 74.1 | 1 | Chemie (1BO) PubChem (263) | |||
| 5 | H (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 786 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 22 - 504 (UniProt: P34897)
| PDB | External Database | Details |
|---|---|---|
| Gly 19 | - | expression tag |
| Ser 20 | - | expression tag |
| His 21 | - | expression tag |
| Ser 423 | Gly 423 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 216269.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 302.4 | |
| All* | Total formula weight | 216571.4 |
