32JN

Structure of the pathogenic variant P157S of Human SHMT2 in the apo open dimeric conformation

Summary for 32JN

• Entry DOI: 10.2210/pdb32jn/pdb
• Related: 32JA 32Jc
• Descriptor: Serine hydroxymethyltransferase, mitochondrial (2 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53799.06

Authors

Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S. (deposition date: 2026-07-13, release date: 2026-09-02)

• Primary citation: Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S.; Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.658 Å)