32JD

Structure of the pathogenic variant P157S of Human SHMT2 in a distorted tetrameric conformation

Summary for 32JD

• Entry DOI: 10.2210/pdb32jd/pdb
• Related: 32JA 32JC
• Descriptor: Serine hydroxymethyltransferase, mitochondrial, PHOSPHATE ION (3 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 108244.29

Authors

Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S. (deposition date: 2026-07-12, release date: 2026-09-02)

• Primary citation: Giardina, G.,Boumis, G.,Di Matteo, A.,Breccia, S.; Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)