32JD

Structure of the pathogenic variant P157S of Human SHMT2 in a distorted tetrameric conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine hydroxymethyltransferase, mitochondrial	polymer	486	54027.2	2	UniProt (P34897)	Homo sapiens (human)	SHMT,Glycine hydroxymethyltransferase,Serine methylase
2	C, D (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4) PubChem (1061)
3	E, F (A, B)	water	water		18.0	30	Chemie (HOH)

Sequence modifications

A, B: 22 - 504 (UniProt: P34897)

PDB	External Database	Details
Gly 19	-	expression tag
Ser 20	-	expression tag
His 21	-	expression tag
Ser 157	Pro 157	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108054.4
Non-Polymers*	Number of molecules	2
	Total formula weight	189.9
All*	Total formula weight	108244.3

*Water molecules are not included.