31MR
CryoEM structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes complexed with an anti-PA-domain monoclonal antibody
Summary for 31MR
| Entry DOI | 10.2210/pdb31mr/pdb |
| EMDB information | 58529 58555 |
| Descriptor | Cell envelope proteinase A, Anti-PA-domain monoclonal antibody (3F2G10) Heavy chain variable region, Anti-PA-domain monoclonal antibody (3F2G10) Light chain variable region, ... (4 entities in total) |
| Functional Keywords | bacterial, protease, complex, antibody, immune evasion, chemokine, protein binding |
| Biological source | Streptococcus pyogenes More |
| Total number of polymer chains | 4 |
| Total formula weight | 198763.00 |
| Authors | Lau, R.J.,Barritt, J.D.,Wu, G.H.Y.,Huemer, C.B.,Matthews, S. (deposition date: 2026-06-12, release date: 2026-07-01) |
| Primary citation | Lau, R.J.,Giblin, S.P.,Sugar, A.,Di Maio, A.,Tassini, G.,Huse, K.,Chorev, D.,Chen, Y.,Wu, G.H.Y.,Huemer, C.B.,Kim, S.Y.,Matthews, J.,Muloud, B.,Chen, L.,McKenna, S.,Xu, Y.,Massai, L.,Muzzi, C.,Ferhati, X.,Necchi, F.,Moriel, D.G.,Feizi, T.,Liu, Y.,Pease, J.E.,Sriskandan, S.,Matthews, S. SpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting PNAS, 2026 Cited by DOI: 10.1073/pnas.2520164123PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.07 Å) |
Structure validation
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