30XM

Engineered pyrrolysyl-tRNA synthetase (PylRS) from Methanosarcina barkeri (Mb) in complex with ATP

Summary for 30XM

• Entry DOI: 10.2210/pdb30xm/pdb
• Related: 2Q7G
• Descriptor: Pyrrolysine--tRNA ligase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: genetic code expansion, substrate recognition specificity, binding pocket plasticity, catalysis, transferase
• Biological source: Methanosarcina barkeri
• Total number of polymer chains: 2
• Total formula weight: 62790.82

Authors

Wanka, V.,Kvasha, D.,Cigler, M.,Heymes-Krauskopf, K.,Ruckgaber, P.,Heider, A.,Fottner, M.,Groll, M.,Lang, K. (deposition date: 2026-05-15, release date: 2026-08-26)

• Primary citation: Wanka, V.,Kvasha, D.,Cigler, M.,Heymes-Krauskopf, K.,Ruckgaber, P.,Heider, A.,Fottner, M.,Groll, M.,Lang, K.; A Genetically Encoded Electrophilic Lysine Derivative Enables Sortase-Mediated Assembly of SUMO Activity-Based Probes; J.Am.Chem.Soc., 2026; DOI: 10.1021/jacs.6c10081

Experimental method

X-RAY DIFFRACTION (1.55 Å)