30TT

14-3-3sigma protein binding to TSC2-wt peptide and molecular glue 22

Summary for 30TT

Entry DOI	10.2210/pdb30tt/pdb
Descriptor	14-3-3 protein sigma, TSC2 peptide pS1254, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	14-3-3, peptide-protein interaction, tsc2, molecular glue, peptide binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	27965.67
Authors	Pennings, M.A.M.,Brunsveld, L. (deposition date: 2026-05-13, release date: 2026-08-26)
Primary citation	Pennings, M.A.M.,Vandenboorn, E.M.F.,Nooren, L.,Ottmann, C.,Brunsveld, L. Mechanistic Insights into Molecular Glue Cooperativity: A 14-3-3 Case Study To Be Published,
Experimental method	X-RAY DIFFRACTION (1.337 Å)

Structure validation