30PU

Structure of a TrkB:BDNF complex

Summary for 30PU

• Entry DOI: 10.2210/pdb30pu/pdb
• Descriptor: BDNF/NT-3 growth factors receptor, Neurotrophic factor BDNF precursor form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: receptor tyrosine kinase, neurotrophin, receptor, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 116392.86

Authors

Briggs, D.C.,McDonald, N.Q. (deposition date: 2026-05-07, release date: 2026-11-04)

• Primary citation: Briggs, D.C.,Duffy, R.,Ateaque, S.,Maslen, S.,Nagaraj, H.,Barde, Y.A.,DiStefano, P.S.,Lindsay, R.M.,Armstrong, P.C.,Peach, C.J.,McDonald, N.Q.; A sulfotyrosine-motif in the human TrkB extracellular domain is required for activation by the agonist antibody ZEB85; PNAS, 2026

Experimental method

X-RAY DIFFRACTION (3 Å)