30PU

Structure of a TrkB:BDNF complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	BDNF/NT-3 growth factors receptor	polymer	392	43895.6	2	UniProt (Q16620)	Homo sapiens (human)	GP145-TrkB,Trk-B,Neurotrophic tyrosine kinase receptor type 2,TrkB tyrosine kinase,Tropomyosin-related kinase B
2	B, D (B, D)	Neurotrophic factor BDNF precursor form	polymer	119	13535.6	2	UniProt (P23560)	Homo sapiens (human)	proBDNF,Abrineurin,Brain-derived neurotrophic factor
3	E (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	F, G, H, I, J (A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG) PubChem (24139)

Sequence modifications

A, C: 3 - 383 (UniProt: Q16620)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 2	-	expression tag
Gln 95	Asn 95	engineered mutation
Gln 121	Asn 121	engineered mutation
Gln 178	Asn 178	engineered mutation
Gln 241	Asn 241	conflict
Gln 280	Asn 280	engineered mutation
Ser 325	Asn 325	engineered mutation
Ala 384	-	expression tag
Ala 385	-	expression tag
Ala 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	114862.4
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	116392.9

*Water molecules are not included.