30LM

Mouse cGAS in complex with DNA and ATP, crystallized in presence of Ap4A.

Summary for 30LM

• Entry DOI: 10.2210/pdb30lm/pdb
• Descriptor: Cyclic GMP-AMP synthase, DNA (5'-D(*AP*TP*CP*TP*GP*TP*AP*CP*AP*TP*GP*TP*AP*CP*AP*GP*AP*T)-3'), ZINC ION, ... (5 entities in total)
• Functional Keywords: innate immunity, cyclic gmp-amp synthase, cgas-sting-pathway, cytosolic dna receptor, nucleotide binding, dna binding protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 108613.32

Authors

Weiland, P.,Kiontke, S.,Bange, G. (deposition date: 2026-05-04, release date: 2026-09-02)

• Primary citation: Weiland, P.,Shivakumar, R.D.,Jalomo-Khayrova, E.,Schmidt, J.,Zegarra, V.,Wang, Y.,Paczia, N.,Kiontke, S.,Burchert, A.,Bange, G.; NUDT2 loss defines quantitative limits for dinucleoside polyphosphate action on the cGAS-STING-TBK1 axis; Biorxiv, 2026; DOI: 10.64898/2026.08.18.745545

Experimental method

X-RAY DIFFRACTION (2.7 Å)