30LM
Mouse cGAS in complex with DNA and ATP, crystallized in presence of Ap4A.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cyclic GMP-AMP synthase | polymer | 364 | 42656.3 | 2 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (house mouse) | cGAMP synthase,cGAS,m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C, D, E, F (C, D, E, F) | DNA (5'-D(*AP*TP*CP*TP*GP*TP*AP*CP*AP*TP*GP*TP*AP*CP*AP*GP*AP*T)-3') | polymer | 18 | 5514.6 | 4 | synthetic construct | ||
| 3 | G, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 4 | H, I, L, M (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 5 | J, N (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) |
Sequence modifications
A, B: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Ser 144 | - | expression tag |
| Gly 145 | - | expression tag |
| Ser 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 107370.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1242.4 | |
| All* | Total formula weight | 108613.3 |
