2ZZB

Crystal structure of human thioredoxin reductase I and terpyridine platinum(II)

Summary for 2ZZB

Entry DOI	10.2210/pdb2zzb/pdb
Related	2ZZ0 2ZZC
Descriptor	Thioredoxin reductase 1, cytoplasmic, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... (5 entities in total)
Functional Keywords	rossmann fold, alternative splicing, cytoplasm, electron transport, fad, flavoprotein, nadp, nucleus, oxidoreductase, phosphoprotein, polymorphism, redox-active center, selenium, selenocysteine, transport
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm . Isoform 4: Cytoplasm. Isoform 5: Cytoplasm: Q16881
Total number of polymer chains	4
Total formula weight	230415.36
Authors	Lo, Y.C.,Ko, T.P.,Wang, A.H.J. (deposition date: 2009-02-09, release date: 2009-08-18, Last modification date: 2023-11-01)
Primary citation	Lo, Y.C.,Ko, T.P.,Su, W.C.,Su, T.L.,Wang, A.H.J. Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1. J.Inorg.Biochem., 103:1082-1092, 2009 Cited by PubMed: 19525010 DOI: 10.1016/j.jinorgbio.2009.05.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation