2ZZB
Crystal structure of human thioredoxin reductase I and terpyridine platinum(II)
Summary for 2ZZB
Entry DOI | 10.2210/pdb2zzb/pdb |
Related | 2ZZ0 2ZZC |
Descriptor | Thioredoxin reductase 1, cytoplasmic, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | rossmann fold, alternative splicing, cytoplasm, electron transport, fad, flavoprotein, nadp, nucleus, oxidoreductase, phosphoprotein, polymorphism, redox-active center, selenium, selenocysteine, transport |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm . Isoform 4: Cytoplasm. Isoform 5: Cytoplasm: Q16881 |
Total number of polymer chains | 4 |
Total formula weight | 230415.36 |
Authors | Lo, Y.C.,Ko, T.P.,Wang, A.H.J. (deposition date: 2009-02-09, release date: 2009-08-18, Last modification date: 2023-11-01) |
Primary citation | Lo, Y.C.,Ko, T.P.,Su, W.C.,Su, T.L.,Wang, A.H.J. Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1. J.Inorg.Biochem., 103:1082-1092, 2009 Cited by PubMed: 19525010DOI: 10.1016/j.jinorgbio.2009.05.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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