2ZZB

Crystal structure of human thioredoxin reductase I and terpyridine platinum(II)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Thioredoxin reductase 1, cytoplasmic	polymer	513	56490.3	4	UniProt (Q16881) Pfam (PF07992) Pfam (PF02852)	Homo sapiens (Human)
2	E, G, J, L (A, B, C, D)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	4	Chemie (FAD)
3	F, I, K, N (A, B, C, D)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	H, M (B, D)	2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride	non-polymer		463.8	2	Chemie (TPT)
5	O, P, Q, R (A, B, C, D)	water	water		18.0	57	Chemie (HOH)

Sequence modifications

A, B, C, D: 0 - 499 (UniProt: Q16881)

PDB	External Database	Details
Met -13	-	expression tag
Ala -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Val -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Cys 498	U 648	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	225961.3
Non-Polymers*	Number of molecules	10
	Total formula weight	4454.0
All*	Total formula weight	230415.4

*Water molecules are not included.