Crystal structure of the copper-bound tyrosinase in complex with a caddie protein from streptomyces castaneoglobisporus obtained by soaking the deoxy-form crystal in dioxygen-saturated solution for 12 hours

Summary for 2ZWG

Related1wxc 1wx2 2zmx 2zmy 2zmz 2zwc 2zwd 2zwe 2zwf
DescriptorTyrosinase, MelC, COPPER (II) ION, ... (5 entities in total)
Functional Keywordstyrosinase, binary complex, type-3 copper, dioxygen, copper transfer, oxidoreductase-metal transport complex, oxidoreductase/metal transport
Biological sourceStreptomyces castaneoglobisporus
Total number of polymer chains2
Total molecular weight46811.58
Matoba, Y.,Sugiyama, M. (deposition date: 2008-12-03, release date: 2009-12-15, Last modification date: 2011-08-31)
Primary citation
Matoba, Y.,Yoshitsu, H.,Jeon, H.J.,Oda, K.,Noda, M.,Kumagai, T.,Sugiyama, M.
Crystallographic evidence of drastic movement of a copper ion toward the substrate tyrosine for starting hydroxylation reaction of tyrosinase
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21130 2.1% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-28