2ZVJ

Crystal structures of rat Catechol-O-Methyltransferase complexed with coumarine-based inhibitor

Summary for 2ZVJ

Entry DOI	10.2210/pdb2zvj/pdb
Related	1H1D 1JR4 1VID 2CL5
Descriptor	Catechol O-methyltransferase, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywords	transferase, methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, cytoplasm, magnesium, membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transmembrane
Biological source	Rattus norvegicus (Rat)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
Total number of polymer chains	1
Total formula weight	25593.51
Authors	Tsuji, E. (deposition date: 2008-11-07, release date: 2009-01-06, Last modification date: 2023-11-01)
Primary citation	Tsuji, E.,Okazaki, K.,Takeda, K. Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor Biochem.Biophys.Res.Commun., 378:494-497, 2009 Cited by PubMed: 19056347 DOI: 10.1016/j.bbrc.2008.11.085 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation