2ZNK
Thrombin Inhibition
Summary for 2ZNK
Entry DOI | 10.2210/pdb2znk/pdb |
Related | 2ZC9 2ZDA 2ZF0 2ZFP 2ZGB 2ZGX |
Related PRD ID | PRD_000599 |
Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total) |
Functional Keywords | blood clotting, hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, gamma-carboxyglutamic acid, glycoprotein, kringle, protease, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P01050 |
Total number of polymer chains | 3 |
Total formula weight | 35702.65 |
Authors | |
Primary citation | Baum, B.,Muley, L.,Smolinski, M.,Heine, A.,Hangauer, D.,Klebe, G. Non-additivity of functional group contributions in protein-ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry. J.Mol.Biol., 397:1042-1054, 2010 Cited by PubMed: 20156458DOI: 10.1016/j.jmb.2010.02.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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